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Kabachnik–Fields reaction
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Kabachnik–Fields reaction : ウィキペディア英語版
Kabachnik–Fields reaction
The Kabachnik–Fields reaction is an organic reaction forming an α-amino phosphonate from an amine, a carbonyl compound and a dialkyl phosphonate. Aminophosphonates are synthetic targets of some importance as phosphorus analogues of α-amino acids (a bioisosteric). This multicomponent reaction was independently discovered by Martin Izrailevich Kabachnik and Ellis K. Fields in 1952.
:
The first step in this reaction is the formation of an imine followed by an addition reaction of the phosphonate P-H bond into the C=N double bond (a Pudovik reaction). A related reaction is the Mannich reaction.
The reaction is accelerated with a combination of dehydrating reagent and Lewis acid. The carbonyl component in the reaction is usually an aldehyde and sometimes a ketone.
==References==


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